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A saturated acyl CoA is degraded by a recurring sequence of four reactions: Would you also like to submit a review for this item? You may have already requested this item.

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Triacylglycerols Are Hydrolyzed by Cyclic AMP-Regulated Lipases The initial event in the utilization of fat as an energy source is the hydrolysis of triacylglycerols by lipases, an event referred to as lipolysis.

As a result, the O -acyl link in carnitine has a high group-transfer potential. These diseases illustrate that the impaired flow of a metabolite from one compartment of a cell to another can lead to a pathological condition.

The final step is the cleavage of 3-ketoacyl CoA by the thiol group of a second molecule of CoA, which yields acetyl CoA and an acyl CoA shortened by two carbon atoms. A special transport mechanism is needed to carry long-chain acyl CoA molecules across the inner mitochondrial membrane.

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Biochemua this process, triacylglycerols are degraded to fatty acids and glycerol, which are released from the adipose tissue and transported to the energy-requiring tissues. Support Center Support Center. First, the lipids must be mobilized. Advanced Search Find a Library. Amino acids are activated for protein synthesis by a similar mechanism Section However, the equilibrium constant for this reaction for carnitine is buochemia 1, apparently because carnatine and its esters are solvated differently from most other alcohols and their esters because of the zwitterionic nature of carnitine.


Glycerol formed by lipolysis is absorbed by the liver and phosphorylated, oxidized to dihydroxyacetone phosphate, and then isomerized to glyceraldehyde 3-phosphate. The shortened acyl CoA then undergoes another cycle of oxidation, starting with the reaction catalyzed by acyl CoA dehydrogenase Figure However, formatting rules can vary widely between applications and fields of interest or study.

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The preceding reactions have oxidized the methylene group at Berb -3 to a keto group. Please choose whether or not you want other users to be able to see on your profile that this library is a favorite of yours.

This reaction is quite favorable because the equivalent of two molecules of ATP is hydrolyzed, whereas only one high-transfer-potential compound is formed. These partial reactions are bkochemia reversible. Hence, glycerol can be converted into pyruvate or glucose in the liver, which contains the appropriate enzymes.

Your rating has been recorded. The next step is the hydration of the double bond between C -2 and C-3 by enoyl CoA hydratase.

Biochemia : Jeremy M. Berg :

Fatty acids are degraded by the repetition of a four-reaction sequence consisting of oxidation, hydration, oxidation, and thiolysis. Please enter recipient e-mail address es. The initial event in the utilization of fat as an energy source is the hydrolysis of triacylglycerols by lipases, an event referred to as lipolysis.

Linked Data More info about Linked Data. This reaction is catalyzed by carnitine acyltransferase I also called carnitine palmitoyl transferase Iwhich is bound to the outer mitochondrial membrane. Citations are based on reference standards. Hence, the stoichiometry of oxidation of palmitoyl CoA is. Find a copy in the library Finding libraries that hold this item The E-mail Address es you entered is are not in a valid format.


National Center for Biotechnology InformationU. Privacy Policy Terms and Conditions. Normally, the transfer of an bery group from an alcohol to a sulfhydryl group is thermodynamically unfavorable. Reaction Sequence for the Degradation of Fatty Acids.

Biochemia – Vicipaedia

Please verify that you are not a robot. Your request to send this item has been completed. The increased level of cyclic AMP then stimulates protein kinase A biochemai, which activates the lipases by phosphorylating them.

Biocheia libraries that hold this item The hydration of enoyl CoA is a prelude to the second oxidation reaction, which converts the hydroxyl group at C -3 into a keto group and generates NADH. W H Freeman ; Ubiquinone is thereby reduced to ubiquinol, which delivers its high-potential electrons to biochekia second proton-pumping site of the respiratory chain Section Create lists, bibliographies and reviews: Medium-chain C 8 -C 10 fatty acids, which do not require carnitine to enter the mitochondria, are oxidized normally in these patients.

In fact, the equilibrium constant for the sum of these reactions is close to bioche,ia. Fatty acids are activated on the outer mitochondrial membrane, whereas they are oxidized in the mitochondrial matrix.