Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.
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Fassihi and co-workers also investigated zero-order delivery of alfuzolin hydrochloride via a gastroretentive system.
Compressed mini-tablet as a biphasic delivery system. Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but technolovy for enteric-coated, delayed-release divalproex: The research that has been conducted on core-in-cup devices showed several interesting and useful techniques as well as beneficial application in terms of the solubility of drugs, the flexibility of delivering both aqueous soluble and aqueous insoluble drugs pose an advantage.
A study by Yang and co-workers proposed a drug delivery system that would be able to treat Geomatrixx pylori -associated gastric ulcers. These barrier layers may also contain drug and serve as matrices to release drug in various release patterns [ 64 ].
He developed a specific punch that is able to change the depth of the cup tablet, thus allowing it to carry various cores in terms of hardness and mass. The barrier layers minimize and therefore delay the interaction of gdomatrix gastrointestinal environment with the active core, by decreasing the surface area available for drug release or by controlling the rate at which the solvent penetrates the layers [ 40 ].
The tablets were composed of PEO and had a diameter of 12 mm. One tablet layer comprises a degradable barrier, and the other layer contains the active in a hydrophilic matrix. Table 2 Summary of the type of polymers influencing the behavior and release characteristics of multilayered tablets.
Namdeo expressed that multilayered tablets have demonstrated promise, possessing various benefits, namely the ability to prevent interactions between drugs and excipients; and by providing an array of release geomatri in one delivery system of either the same or different drugs, treatment for conditions that require a regimen of more than one drug, immediate drug release using a disintegrating monolithic matrix in order to achieve an initial peak in plasma drug level, delayed drug release using an eroding monolithic matrix which may deliver another active drug to a geomateix part of the geomatrxi tract, providing controlled drug release instituting a swellable monolithic matrix and better control and regulation of release profiles by retarding initial burst release and achieving zero-order kinetics [ 64 geonatrix.
These polymers act as barriers to control drug release.
Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery
Polymers are the essential drug carriers of multilayered matrix tablets and their properties are an important factor in the behavior of these devices. It is in essence, water soluble at high pH values and water-insoluble at low pH values. Caffeine and ibuprofen were used as model drugs as they have tecunology solubilities and allowed for a comparison on the drug release profiles.
The device consisted of a core that contained a therapeutic agent, an osmotic agent and poly vinylpyrrolidone PVP. These geometric manipulations may also be employed to develop drug delivery systems for the treatment of specialized biological conditions where zero-order drug release is not optimal, for example chronotherapy for heart conditions [ 46 ] or the scheduled treatment of asthma and inflammation [ 47 ].
Correlation between drug dissolution and polymer tfchnology Effect of tecbnology solubility on polymer hydration and drug dissolution from polyethylene oxide PEO matrix tablets. Zero-order release was achieved when the slowly erodible polymers were used and parabolic techbology release was achieved when rapidly erodible polymers were used when diltiazem hydrochloride was incorporated as a model drug.
Future research may thus focus further on modifying these fechnology and using the basic technological principles to develop novel systems that may be able to be applied in broader and more complicated drug delivery, such as in the treatment of more complex diseases with a larger drug regimen that requires more individualized types of drug release. This type of release could be useful for drugs that need a high plasma concentration immediately for therapeutic efficacy where zero-order drug release kinetics is not required.
The controlled release layer delivered metformin while the rapid release layer delivered glimepiride.
Geomatrix Technology – Oral Drug Delivery – Doctor Steve Abel
A bilayered tablet for the delivery of propranolol hydrochloride was developed by Patra and co-workers. The hydrochloride salts of weakly basic drugs had a slower release rate than neutral drugs [ 66 ]. Elementary module containing a concave base side and a convex base side. Introduction Modified or controlled release oral drug delivery systems have, geomatdix the last few decades, been shown to offer advantages over conventional systems [ 1 — 6 technolpgy. Press coating is a good technique for producing this type of time-dependent release.
An indented core tablet strategy for preparing monolithic osmotic pumps was developed by Longxiao and co-workers. Hydrophilic polymers were employed as drug core matrices due to their swelling ability [ 73 — 76 ].
These factors ultimately influence diffusion path length as well as the diffusion co-efficient.
Multilayered Osmotic Devices An indented core tablet strategy for preparing monolithic osmotic pumps was developed by Longxiao and co-workers.
The tablets were prepared using a unique designed punch set. Smart People Smart Solutions. Coupling of diffusion and relaxation. Polymers for sustained macromolecule release: When the solvent penetrates the core layer, the core swells and dissolves, this causes the coating shell to break thereby rapidly releasing the drug [ 4 ]. This type of variable release is extremely useful for the delivery of specific drugs that need both rapid and sustained release.