Keywords aplastic anemia, chloramphenicol, mice, shrimps. Pengaruh residu khloramfenikol dalam udang windu terhadap kejadian anemia aplastik pada. Sari Pediatri, Vol. 7, No. 1, Juni Judul: Masalah pada Tata Laksana Anemia Aplastik. Background: Aplastic anemia is a well-recognized form of marrow failure. The incidence of aplastic anemia is subjected to wide variation.

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Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy. Masalah Khloramfenikol pada produksi udang di Indonesia. Golongan Tetrasiklin dan Khloramfenikol, Farmakologi dan Terapi. HSCT from a matched sibling donor is preferred for children and young adults with severe AA, and IST is employed when HSCT is not feasible due to age, lack of a histocompatible sibling, co-morbidities, or by patient choice.

Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte aplaxtik factor in children with acquired aplastic anemia.

Immunosuppressive therapy for aplastic anemia in children: Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy. Hematopoiesis Immune attack leads to marrow failure. Proceedings of the National Academy of Sciences.

Medical Journal of Lampung University

Lippincott Williams and Wilkins publishers; A minority of AA cases may share pathophysiologic basis with inherited marrow failure syndromes. Recovery of autologous hematopoiesis in patients who failed to engraft after stem cell transplant and responsiveness to immunosuppressive therapies are the major clinical evidences supporting an immune pathophysiology underlying acquired AA. Progress in donor selection through high-resolution HLA typing technology has likely contributed to decreased graft rejection and better survival [ 82 ] and recently reported outcomes for MUD rival those for an HLA-matched sibling transplant in children and aplaastik adults [ 8384 ].


The association of medical drug use to AA is of great importance, as it is devastating to patients and physicians and presents serious legal consequences and problems in pharmaceutical drug development [ 4 ]. Bancroft JD, Gamble M. While it is generally believed that h-ATG administration leads to depletion of immune competent cells, its exact mechanism of action remains unclear [ 40 ].

British Committee for Standards in Haematology http: Departemen Perikanan dan Kelautan. Summary Evidence has accumulated in the recent years further jjurnal an immune-mediated process underlying AA pathogenesis.


Antilymphocyte globuilin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Conclusion In recent years, further evidence has accumulated to strengthen the hypothesis that bone appastik failure in AA results from immunologic destruction of hematopoietic stem and progenitor cells.

The majority of responses to IST are not complete, notwithstanding, hematologic response almost always equates to cessation of transfusion, and multiple studies have shown a strong correlation between hematologic response and long term survival [ 4549 ].

Evolution of clonal cytogenetic abnormalities in aplastic anemia. Frickhofen N, Rosenfeld SJ. Maciejewski JP, Selleri C. Antithymocyte globulin and cyclosporine for severe aplastic anemia. Monosomy 7 has been linked to exogenous use of G-CSF in AA [ 3637 ] and laboratory studies suggest that aneuploid clones expand in an abnormal cytokine milieu rich in G-CSF due to the presence of a short G-CSF receptor isoform, which signals proliferation but not differentiation [ 38 ]. Aplastic Anemia, Acquired and Inherited.



Immunosuppressive treatment of aplastic anemia with antithymocyte globuilin and cyclosporine. Clinically, r-ATG appears to be more immunosuppressive as a more prolonged lymphopenia is observed with this agent compared to h-ATG [ 52 ].

A hospital-based prospective multicentre study. Incidence of aplastic anemia and agranulocytosis in Latin America: Daclizumab, a humanized monoclonal antibody to the interleukin-2 receptor, improved blood counts and relieved transfusion requirements in 6 of 16 evaluable patients; the outpatient regimen had little toxicity [ 69 ].

Red blood cell transfusion in clinical practice. Hepatitis Associated Aplastic Anemia: Interesting changes occurred at the 30 days duration treatment where mild hypochrome anisocytosis and hypochrome anisocytosis occurred marked by mildly pale cellular colorizations with cellular forms jurnnal from normal, microerythrocyte, to macroerythrocyte. Am J Hematol ;7: Author information Copyright and License information Disclaimer.